在一个平凡的夜晚,美丽的空中小姐珍妮和朋友宝拉登上天空航空公司飞往堪萨斯的318次航班,执行有一次看似平常的飞行任务。一如既往,这架小型飞机上聚集着各色各样的乘客,珍妮耐心友善地服务乘客,却不知危险正渐渐逼近。飞行途中,一名肥胖的乘客神态异常,在吐了珍妮一身秽物之后,竟发狂地冲向驾驶舱要求下飞机。机舱内一片混乱,万般无奈之下,飞机只得迫降于洛杉矶机场。而在这一过程中,宝拉也被胖子啃噬,情况危急。 机组成员和乘客来到洛杉矶机场,却发现偌大的机场内空无一人,他们仿佛被世人囚禁于一个隔离的区域中……
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