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香港卧底探员志杰(吴京 饰)不惜变成瘾君子,潜伏犯罪集团侦查幕后主脑洪先生(古天乐 饰);直属上司兼叔父华哥(任达华 饰)决定终止行动,志杰却身份败露且人间蒸发。华哥违抗命令私自搜寻,辗转得悉志杰已被关进泰国某监狱,遂只身前赴营救。 泰国警察阿猜(托尼·贾 饰)为筹钱医治患血癌的女儿转任狱警,负责看管志杰。志杰与阿猜语言不通、身份对立,却竟是唯一可拯救阿猜女儿的骨髓捐赠者,阿猜必须保住志杰的性命;但狱长(张晋 饰)为确保幕后交易运作畅正常,必须铲除志杰。 身体虚弱的洪先生带同胞弟(恭硕良 饰)突然出现,准备进行心脏移植手术自救;原来整个监狱是洪先生操控的活人体器官供应市场……